Projects

The Alzheimer’s Disease Sequencing Project (ADSP) was established in February 2012 as a Presidential Initiative to fight Alzheimer’s Disease (AD). Developed jointly by the National Institute on Aging (NIA) and the National Human Genome Research Institute (NHGRI), the specific aims of the ADSP are to 1) identify protective genomic variants in older adults at risk for AD, 2) identify new risk variants among AD cases, and 3) examine these factors in multi-ethnic populations to identify therapeutic targets for disease prevention.

The Asian Cohort for Alzheimer’s Disease (ACAD) is an international collaboration with the goal of compiling a robust sample size of Asian American and Canadian subjects for Alzheimer’s disease (AD) research. Making up 6% and 10% of the US and Canadian populations respectively, Asians are the fastest-growing populations in both countries yet they are underrepresented in AD research. ACAD aims to address this gap by starting with a cohort of individuals of Chinese, Korean, and Vietnamese ancestry, and later extending to other major Asian populations in both countries.

NIA Coordinating Genome Center of Alzheimer’s Disease (GCAD) is a five-year/$10.8M U54 Cooperative Agreement/Specialized Center funded by NIA (U54-AG052427) to facilitate AD gene discovery by coordinating analysis of all AD-relevant data. GCAD will assemble all data generated by the Alzheimer’s Disease Sequence Project (ADSP) from both the Discovery Phase and the Follow-Up Phase, and all data from non-ADSP sources.

GCAD consists of three cores:

• Administrative (Core A);
• Data Management, Harmonization, and Information Transfer Core (Core B);
• Biostatistics and Data Analysis Core (Core C).

GCAD will:

• Create and support a collaborative network of all GCAD, ADSP, RFA AG16002, and other AD genetics investigators;
• Harmonize all genetic and phenotype data and fully annotate all variants;
• Design all harmonization and annotation protocols, and plan and implement analysis for all data;
• Broadly distribute primary data, harmonized annotated analysis-ready files, and analyses results including depositing appropriate data into qualified access databases [National Institute on Aging Genetics of Alzheimer’s Disease Storage site (NIAGADS) and database of Genotypes and Phenotypes (dbGaP)].

NIA Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS) is a genetics data repository set up by the National Institute of Aging (NIA) to facilitate access by qualified investigators to genotypic data for Alzheimer’s disease (AD). We propose to expand NIAGADS into a one-stop shopping data warehouse and portal for AD genetics that reflects the latest advances in genetics research and high-throughput genotyping and next-generation sequencing technologies. The completed repository will include a genomics database for AD genetics; enhancement for next-generation sequencing data, secondary data, and analysis results; and accessible workflows and secondary data from various AD genetics projects.